Millennium Nucleus in Cardiovascular Magnetic Resonance
*Ventricles and atria
Cardiovascular diseases (CVD) affect directly to the heart and blood vessels. Some DVC are: high blood pressure (increase in the pressure applied by the blood over the arterial walls), coronary heart disease (its main appearance is acute myocardial infarction), cerebrovascular disease (cerebrovascular accident), peripheral vascular disease, cardiac insufficiency, cardiac valves disease, congenital heart disease and cardiomyopathy.
DVC are the first cause of death around the world, resulting in around 17 million deaths annually. The World Health Organization (WHO) foresees that by the year 2030, 23.6 millions of people will die due to these diseases worldwide. Whereas, according to the National Health Survey of 2017 carried out in Chile, it is revealed that annually a 30% of deaths are associated to these pathologies.
The Millennium Nucleus in Cardiovascular Magnetic Resonance, Cardio MR, is an excellence investigation center financed by the Millenium Science Initiative of the Ministry of Science, Technology, Knowledge and Innovation of Chile.
The Host Institution of Cardio MR is the Pontifical Catholic University of Chile. There are also other universities and entities participating, amongst them the Hospital Sótero del Río. The alliance with this hospital is fundamental to apply the knowledge achieved in the center, and to get an important impact in society.
Sergio Uribe (PhD) and Marcelo Andía (MD-PhD) are Director and Alternate Director at the Core, whom together with Cecilia Besa (MD), Carlos Sing-Long (PhD) and Daniel Hurtado (PhD) are the main investigators in this research center.
Obtain quantitative information about blood circulation and the mechanics of the cardiovascular system, through the development of magnetic resonance images, which are not invasive and are ionizing radiation free.
Our mission as Millennium Nucleus in Cardiovascular Magnetic Resonance, Cardio MR, is to move forward in the knowledge about the heart’s physiology through non-invasive magnetic resonance images and mathematical models, providing new tools for scientists and doctors for a better diagnosis and treatment for cardiovascular illnesses.
To approach this challenge and in order to become an institution of reference in the subject, at Cardio MR we gather a multidisciplinary group, formed by scientists from different areas of knowledge and doctors, which collaboratively move forward into generating knowledge regarding the cardiovascular system.
ACQUISITION OF CARDIOVASCULAR IMAGES
With the aim of improving the time-space resolution of the cardiovascular magnetic resonance images, through the development and adjustment of new methods of reconstruction from sub-sampled data that develop the redundancy of information.
QUANTIFICATION OF CARDIOVASCULAR PARAMETERS
Quantify biomechanical and hemodynamic parameters in a non-invasive manner in the vessel wall and in the myocardium, integrating numerical models with images of cardiovascular magnetic resonance of time-space high resolution.
PRELIMINAR CLINICAL TRIALS
Find new quantitative parameters of the cardiac function and hemodynamic from the cardiovascular magnetic resonance images, that allow differentiating between healthy volunteers and patients with atherosclerosis and cardiac insufficiency.
TRIALS IN A PRE CLINIC MODEL
Identify early biomarkers derived from the cardiovascular magnetic resonance images that allow predicting the progression of the atherosclerotic disease and cardiac insufficiency.
The Cardio MR team, through the Pontifical Catholic University of Chile and the Center of Biomedical Images UC https://www.mri.cl/ has access to a magnetic resonator Philips Achieva 1.5T and a resonator Philips Ingenia 3T, to develop new sequences of magnetic resonance, as well as advanced sequences that are in process of development. In addition, we possess a pre-clinic resonator Bruker ICON 1T.
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